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1965 Silvertone Harmony model S1478
With Original Fibreboard Case
~ Page 34;  9 Jan, 2009;  Registering bridge position ~
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The bridge plate's longitudinal intonation bridge datum and latteral neck alignement register is determined and marked with masking tape before the bridge is removed for drilling it's plate's screw holes and screwing down the bridge plate.
The bridge plate can then be put back at the exact datum register for drilling the plate's screw holes (which were slightly different than the factory holes ....which is not unusual since the factory used machines that didn't have the best tolerances for guitar-making back then.
The original saddles would have had to be shimmed.  I would have used an exact fit blade of a stainless feeler gauge to shim between the saddles and the base plate, for a good tight contact with the bridge plate to communicate best with the body's resonance.  The original bridge used a sheet of mylar over a felt pad as shown in the bridge plate in the can below.  But as it turned out, ....using the saddles from this plate on the original bridge plate was such a tight fit that no shims were needed, although I will need to shim the old saddles onto this different plate using an exact sized blade from the feeler gauge set.
When drilling delicate or exacting parts such as through a plastic pickguard into a guitar body;  If a drill press with a gimbeled holding jig and a fully variable slow speed is not available, then I highly suggest using a hand drill which is MUCH easier to control slow speed, angle and pressures.